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Chamaileon: Cross-Context Binder Design with Contextualized Modeling and Mixed Sampling

7 upvotes · 26 JUL 2026 · Hengyuan Cao, Shizhuo Cheng, Mingxuan Liu et al.

This paper introduces Chamaileon, a new method for designing protein binders that can model multiple targets and conformations, which could help researchers and practitioners design more advanced proteins with specific functions. Practitioners might care about this approach because it could lead to breakthroughs in structural biology and protein engineering.

protein designcross-context modelingsequence-structure modelingmulti-target bindinggenerative models