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14 OCT 2026 · Podcast · Latent Space: The AI Engineer Podcast

Lab-in-the-Loop at Compute Speed — Ian Quigley, Leash Bio

Ian Quigley, co-founder and CEO of Leash Bio, discusses the challenges and innovations in small molecule drug discovery using DNA encoded libraries (DELs) and machine learning. The episode covers the technical details of DELs, lessons from …

DNA encoded libraries small molecule drug discovery machine learning models protein-ligand binding combinatorial chemistry Kaggle competition Hermes model chemist bias activity cliffs protein mutations language models lab-in-the-loop drug discovery scaling ADMET properties experimental rigor reinforcement learning binding prediction structural biology chemical library design

1 JUL 2026 · Podcast · Machine Learning Street Talk (MLST)

The Benchmark With No Instructions — ARC-AGI-3 (winning team!)

Tim Scarfe interviews the Tufa Labs ARC-AGI-3 team to dissect their winning approach on the ARC-AGI-3 benchmark, focusing on how their system discovers goals and balances exploration with action efficiency. The episode explores the challeng…

ARC-AGI-3 benchmark goal acquisition action efficiency exploration vs exploitation language models planning in AI coding agents requirements engineering core knowledge priors abstraction synthesis reinforcement learning AI safety bitter lesson neural guided search LLM reasoning software engineering AI benchmark design general intelligence